Human G-Protein Coupled Receptor 56 (GPR56) Protein

Background

Members of this family exhibit elongated N-termini and harbor multiple functional domains. They are implicated in immune system functions and central nervous system activities. Through alternative splicing, numerous transcript variants are generated, encoding diverse isoforms. ADGRG1, also known as GPR56, is a member of the adhesion GPCR family widely expressed in the central nervous system, immune cells, and various tissues. It plays crucial roles in brain development, particularly in cortical formation. ADGRG1 also regulates cell adhesion, migration, and tumor progression. Mutations in ADGRG1 are associated with bilateral frontoparietal polymicrogyria (BFPP), a neurological disorder. Beyond its developmental role, ADGRG1 has been implicated in cancer and immune modulation, making it a target of interest for therapeutic interventions.