Human F2R (Proteinase-activated receptor 1) ELISA Kit
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name
Human F2R (Proteinase-activated receptor 1) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH1062
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P25116 |
| Alias | F2R,protease-activated receptor 1,coagulation factor II, thrombin receptor,CF2R,HTR,PAR-1,PAR1,TR |
| Background | Elisa kits for F2R |
| Status | RUO |
Proteinase-Activated Receptor 1 (F2R), or PAR1, is a G protein-coupled receptor activated by thrombin, a serine protease involved in coagulation and cellular signaling. PAR1 activation occurs through proteolytic cleavage of its N-terminal domain, exposing a tethered ligand that activates the receptor. PAR1 couples to Gq, Gi, and G12/13 proteins, triggering diverse signaling pathways, including phospholipase C (PLC), MAPK, and Rho-mediated pathways. PAR1 is widely expressed in endothelial cells, platelets, smooth muscle cells, and neurons, where it regulates thrombosis, inflammation, vascular permeability, and tissue repair. In platelets, PAR1 activation promotes aggregation and thrombus formation, while in endothelial cells, it modulates vascular integrity and inflammation. Dysregulation of PAR1 contributes to thrombotic disorders, cancer progression, and inflammatory diseases. PAR1 antagonists, such as vorapaxar, are clinically used to reduce thrombotic events in patients with cardiovascular disease. Targeting PAR1 offers therapeutic benefits in thrombosis, cancer, and inflammatory vascular disorders.
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