Human E2F Transcription Factor 7 (E2F7) ELISA Kit

Este producto es parte de E2F - E2F Transcription Factor
Human E2F Transcription Factor 7 (E2F7) ELISA Kit
715€ (96 tests)

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Name
Human E2F Transcription Factor 7 (E2F7) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx387030
Tested Applications
ELISA

Description

Human E2F Transcription Factor 7 (E2F7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human E2F7 concentrations.

Documentos del producto

Instrucciones
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Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Transcription factor E2F7
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q96AV8
Gene ID
144455
OMIM
612046
Alias
E2F-7
Background
Elisa Kits for: E2F7
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

E2F7 is an atypical E2F transcription factor that functions as a repressor of E2F target genes, particularly those involved in DNA replication and cell cycle progression. Unlike classical E2Fs, E2F7 contains two DNA-binding domains but lacks a transactivation domain, enabling it to directly bind and repress target promoters without the involvement of RB proteins. E2F7 is upregulated during the G2/M phase and acts as a negative feedback regulator to suppress E2F-driven proliferation. It plays a key role in cellular stress responses, where it regulates genes involved in DNA damage repair, such as p53 target genes, to maintain genomic stability. Dysregulation of E2F7 contributes to tumorigenesis by disrupting cell cycle checkpoints and DNA damage responses. Knockout studies show increased sensitivity to DNA damage, defective cell cycle arrest, and aberrant proliferation, underscoring E2F7’s role in genomic maintenance, stress response, and tumor suppression.

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