Human Transcription Factor E2F4 (E2F4) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for E2F4
proveedor
Abbexareference
abx387029Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Transcription Factor E2F4 (E2F4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human E2F4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
E2F4 is a member of the E2F family that predominantly functions as a transcriptional repressor to regulate genes involved in cell cycle arrest and differentiation. Unlike E2F1-3, which activate proliferation-related genes, E2F4 associates with pocket proteins such as p107, p130, and RB to repress E2F target genes during quiescence (G0 phase) and early G1. It is highly expressed in differentiated and non-proliferative cells, where it helps maintain cellular homeostasis and tissue stability. E2F4 is essential for hematopoiesis, where it promotes the differentiation of erythroid and myeloid cells by suppressing proliferation signals. Dysregulation of E2F4 has been linked to cancers and developmental disorders due to disrupted cell cycle arrest mechanisms. Knockout models exhibit defects in hematopoiesis, impaired differentiation, and embryonic lethality, underscoring E2F4’s critical role in maintaining cellular quiescence, differentiation, and growth suppression.
Características del producto
category
ELISA Kits
immunogen target
Transcription Factor E2F4 (E2F4)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.15 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
E2F-4
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
E2F4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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