Human Transcription Factor E2F4 (E2F4) ELISA Kit
715€ (96 tests)
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Name
Human Transcription Factor E2F4 (E2F4) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx387029
Tested Applications
ELISA
Description
Human Transcription Factor E2F4 (E2F4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human E2F4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documentos del producto
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Transcription Factor E2F4 (E2F4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.15 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q16254 |
| Gene ID | 1874 |
| OMIM | 600659 |
| Alias | E2F-4 |
| Background | Elisa Kits for: E2F4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
E2F4 is a member of the E2F family that predominantly functions as a transcriptional repressor to regulate genes involved in cell cycle arrest and differentiation. Unlike E2F1-3, which activate proliferation-related genes, E2F4 associates with pocket proteins such as p107, p130, and RB to repress E2F target genes during quiescence (G0 phase) and early G1. It is highly expressed in differentiated and non-proliferative cells, where it helps maintain cellular homeostasis and tissue stability. E2F4 is essential for hematopoiesis, where it promotes the differentiation of erythroid and myeloid cells by suppressing proliferation signals. Dysregulation of E2F4 has been linked to cancers and developmental disorders due to disrupted cell cycle arrest mechanisms. Knockout models exhibit defects in hematopoiesis, impaired differentiation, and embryonic lethality, underscoring E2F4’s critical role in maintaining cellular quiescence, differentiation, and growth suppression.
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