Transcription Factor E2F4 (E2F4) Antibody
260€ (50 µl)
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Name
Transcription Factor E2F4 (E2F4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx212981
Tested Applications
ELISA, IHC
Description
E2F4 Antibody is a Rabbit Polyclonal against E2F4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transcription Factor E2F4 (E2F4) Immunogen: Synthetic peptide of human E2F4. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16254 |
| Gene ID | 1874 |
| OMIM | 600659 |
| Alias | E2F-4 |
| Background | Antibody anti-E2F4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
E2F4 is a member of the E2F family that predominantly functions as a transcriptional repressor to regulate genes involved in cell cycle arrest and differentiation. Unlike E2F1-3, which activate proliferation-related genes, E2F4 associates with pocket proteins such as p107, p130, and RB to repress E2F target genes during quiescence (G0 phase) and early G1. It is highly expressed in differentiated and non-proliferative cells, where it helps maintain cellular homeostasis and tissue stability. E2F4 is essential for hematopoiesis, where it promotes the differentiation of erythroid and myeloid cells by suppressing proliferation signals. Dysregulation of E2F4 has been linked to cancers and developmental disorders due to disrupted cell cycle arrest mechanisms. Knockout models exhibit defects in hematopoiesis, impaired differentiation, and embryonic lethality, underscoring E2F4’s critical role in maintaining cellular quiescence, differentiation, and growth suppression.
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