Human E2F Transcription Factor 1 (E2F1) Protein
494€ (100 µg)
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Name
Human E2F Transcription Factor 1 (E2F1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx653229
Tested Applications
ELISA, WB, SDS-PAGE
Description
Human E2F Transcription Factor 1 (E2F1) Protein is a Recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | E2F Transcription Factor 1 (E2F1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Val88-Phe437 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 40.94 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose and 1% Mannitol. |
| Availability | Shipped within 7-15 working days. |
| Storage | Aliquot and store at -20 °C to 80°C. Avoid repeated freeze-thaw cycles. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q01094 |
| Gene ID | 1869 |
| OMIM | 189971 |
| Alias | E2F-1,RBAP1,RBBP3,RBP3,Retinoblastoma-binding protein 3,Retinoblastoma-associated protein 1 |
| Background | Protein E2F1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile water to produce a stock solution. Concentration: Prior to lyophilization: 0.8 mg/ml |
Background
E2F1 is a member of the E2F family of transcription factors, which are critical regulators of cell cycle progression, DNA replication, and apoptosis. E2F1 drives the transition from G1 to S phase by activating genes required for DNA synthesis and cell proliferation, including cyclins and replication factors. It is tightly regulated by the retinoblastoma protein (pRB), which suppresses its activity under growth-inhibitory conditions. E2F1 also induces apoptosis under cellular stress or DNA damage by activating pro-apoptotic genes such as p53 and caspases. Dysregulation of E2F1 contributes to tumorigenesis by promoting uncontrolled proliferation and resistance to cell death. In cancer, overexpression of E2F1 is often observed, correlating with poor prognosis and enhanced tumor growth. Knockout models reveal defects in cell cycle progression and reduced apoptosis, emphasizing its dual role in proliferation and programmed cell death.
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