Human E2F Transcription Factor 1 (E2F1) Protein
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935106861
info@markelab.com
Precio
494€ (100 µg)
Protein E2F1
proveedor
Abbexareference
abx653229Tested Applications
ELISA, WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human E2F Transcription Factor 1 (E2F1) Protein is a Recombinant Human protein expressed in E. coli.
Background
E2F1 is a member of the E2F family of transcription factors, which are critical regulators of cell cycle progression, DNA replication, and apoptosis. E2F1 drives the transition from G1 to S phase by activating genes required for DNA synthesis and cell proliferation, including cyclins and replication factors. It is tightly regulated by the retinoblastoma protein (pRB), which suppresses its activity under growth-inhibitory conditions. E2F1 also induces apoptosis under cellular stress or DNA damage by activating pro-apoptotic genes such as p53 and caspases. Dysregulation of E2F1 contributes to tumorigenesis by promoting uncontrolled proliferation and resistance to cell death. In cancer, overexpression of E2F1 is often observed, correlating with poor prognosis and enhanced tumor growth. Knockout models reveal defects in cell cycle progression and reduced apoptosis, emphasizing its dual role in proliferation and programmed cell death.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
E2F Transcription Factor 1 (E2F1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in sterile water to produce a stock solution.
tested applications
ELISA, WB, SDS-PAGE
size 1
100 µg
size 2
1 mg
observerd MW
Molecular Weight: Calculated MW: 40.94 kDa Concentration: Prior to lyophilization: 0.8 mg/ml Sequence Fragment: Val88-Phe437 Tag: N-terminal His tag
expression
Recombinant
purity
> 90% (SDS-PAGE)
buffer
Prior to lyophilization: PBS, pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose and 1% Mannitol.
storage
Store at 2-8 °C for up to one week. Store between -20 °C and -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
E2F1
dry ice
No
availability
Shipped within 7-15 working days.
alias
E2F-1,RBAP1,RBBP3,RBP3,Retinoblastoma-binding protein 3,Retinoblastoma-associated protein 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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