E2F Transcription Factor 1 (E2F1) Antibody
312€ (60 µl)
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Name
E2F Transcription Factor 1 (E2F1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001684
Tested Applications
IF/ICC
Description
E2F1 Antibody is a Rabbit Polyclonal antibody against E2F1. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: E2F Transcription Factor 1 (E2F1) Immunogen: A synthetic peptide corresponding to human E2F1 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IF/ICC: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01094 |
| Gene ID | 1869 |
| NCBI Accession | NP_005216.1 |
| Alias | E2F-1,RBAP1,RBBP3,RBP3,Retinoblastoma-binding protein 3,Retinoblastoma-associated protein 1 |
| Background | Antibody anti-E2F1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
E2F1 is a member of the E2F family of transcription factors, which are critical regulators of cell cycle progression, DNA replication, and apoptosis. E2F1 drives the transition from G1 to S phase by activating genes required for DNA synthesis and cell proliferation, including cyclins and replication factors. It is tightly regulated by the retinoblastoma protein (pRB), which suppresses its activity under growth-inhibitory conditions. E2F1 also induces apoptosis under cellular stress or DNA damage by activating pro-apoptotic genes such as p53 and caspases. Dysregulation of E2F1 contributes to tumorigenesis by promoting uncontrolled proliferation and resistance to cell death. In cancer, overexpression of E2F1 is often observed, correlating with poor prognosis and enhanced tumor growth. Knockout models reveal defects in cell cycle progression and reduced apoptosis, emphasizing its dual role in proliferation and programmed cell death.
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