Human Dynein Light Chain 1, Cytoplasmic (DYNLL1) Protein
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Description
Human Cytoplasmic Dynein Light Chain 1 Protein is a recombinant protein from Human produced in E. coli. Recombinant Human Cytoplasmic Dynein Light Chain 1 is produced by our E.coli expression system and the target gene encoding Met1-Gly89 is expressed with a 6His tag at the N-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Dynein Light Chain 1, Cytoplasmic (DYNLL1) |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 12.5 kDa Sequence Fragment: Met1-Gly89 Tag: N-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM TrisHCl, 200mM NaCl, 1mM DTT, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | P63167 |
| Alias | DLC1,DLC8,DNCL1,DNCLC1,LC8,LC8a,PIN,hdlc1,8 kDa dynein light chain |
| Background | Protein DYNLL1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Dynein light chain 1, cytoplasmic (DYNLL1) is a protein that plays a critical role in the regulation of motor protein activity, particularly the dynein motor complex, which is involved in intracellular transport and cell division DYNLL1 functions as part of the dynein complex by binding to the dynein intermediate and heavy chains, facilitating the movement of cellular cargo along microtubules in the cytoplasm This process is essential for the transport of vesicles, organelles, and protein complexes within the cell, and for maintaining the proper positioning of mitotic spindles during cell division DYNLL1 also has a role in regulating the actin cytoskeleton and modulating various signaling pathways, including those involved in apoptosis and stress responses Dysregulation of DYNLL1 has been linked to neurodegenerative diseases, where defective cellular transport and organelle dysfunction contribute to neuronal damage It is also implicated in cancer, where its interaction with key signaling pathways can influence tumor cell migration and metastasis DYNLL1’s essential functions in intracellular trafficking and cellular signaling underscore its importance in maintaining normal cellular function and tissue homeostasis
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