Dynein Light Chain 1, Cytoplasmic (DYNLL1) Antibody
312€ (60 µl)
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935106861
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name
Dynein Light Chain 1, Cytoplasmic (DYNLL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004392
tested applications
WB
Description
DYNLL1 Antibody is a Rabbit Polyclonal antibody against DYNLL1. Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Dynein Light Chain 1, Cytoplasmic (DYNLL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P63167 |
| Gene ID | 8655 |
| NCBI Accession | NP_003737.1 |
| Alias | DLC1,DLC8,DNCL1,DNCLC1,LC8,LC8a,PIN,hdlc1,8 kDa dynein light chain |
| Background | Antibody anti-DYNLL1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Dynein light chain 1, cytoplasmic (DYNLL1) is a protein that plays a critical role in the regulation of motor protein activity, particularly the dynein motor complex, which is involved in intracellular transport and cell division DYNLL1 functions as part of the dynein complex by binding to the dynein intermediate and heavy chains, facilitating the movement of cellular cargo along microtubules in the cytoplasm This process is essential for the transport of vesicles, organelles, and protein complexes within the cell, and for maintaining the proper positioning of mitotic spindles during cell division DYNLL1 also has a role in regulating the actin cytoskeleton and modulating various signaling pathways, including those involved in apoptosis and stress responses Dysregulation of DYNLL1 has been linked to neurodegenerative diseases, where defective cellular transport and organelle dysfunction contribute to neuronal damage It is also implicated in cancer, where its interaction with key signaling pathways can influence tumor cell migration and metastasis DYNLL1’s essential functions in intracellular trafficking and cellular signaling underscore its importance in maintaining normal cellular function and tissue homeostasis
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