Human Docking Protein 3 (DOK3) Protein

Este producto es parte de DOK - Docking protein
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221€ (10 µg)

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935106861
info@markelab.com
name
Human Docking Protein 3 (DOK3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx165873
tested applications
WB, SDS-PAGE

Description

Docking Protein 3 is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Docking Protein 3 (DOK3)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 57.8 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ile128-Cys385
Tag: N-terminal His tag and GST tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
DOK3, DOKL, docking protein 3,Downstream of tyrosine kinase 3
Background
Protein DOK3
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Docking protein 3 (DOK3) is a unique member of the DOK family, characterized by its selective expression in lymphoid tissues and its critical role in B-cell receptor (BCR) signaling. Unlike DOK1 and DOK2, DOK3 predominantly functions in modulating adaptive immune responses. It acts as a negative regulator of BCR signaling by interacting with various kinases and phosphatases, thereby preventing hyperactivation of B cells. This function is crucial for maintaining immune tolerance and preventing autoimmune disorders. DOK3 has also been implicated in the regulation of inflammation and the production of cytokines in macrophages. Dysregulation of DOK3 expression or function has been linked to immune deficiencies and certain lymphoid malignancies, highlighting its importance in immune regulation and cellular signaling pathways.

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