Human Docking Protein 1 (DOK1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DOK1
proveedor
Abbexareference
abx386967Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Docking Protein 1 (DOK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DOK1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Docking protein 1 (DOK1) serves as an adaptor protein involved in cellular signaling pathways, particularly those linked to tyrosine kinase receptors and cytokine receptors. DOK1 lacks intrinsic enzymatic activity but facilitates signal transduction by linking membrane-bound receptors to downstream effectors. It plays a critical role in regulating cell proliferation, differentiation, and apoptosis by acting as a negative regulator of mitogenic signaling pathways. DOK1 is highly expressed in hematopoietic cells and is instrumental in immune responses. Dysregulation of DOK1 has been implicated in oncogenesis, particularly in hematologic malignancies, where it acts as a tumor suppressor by inhibiting excessive cellular proliferation and survival signals. Its interactions with Ras-GAP and other signaling molecules underline its importance in maintaining cellular homeostasis.
Características del producto
category
ELISA Kits
immunogen target
Docking Protein 1 (DOK1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.094 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
Downstream of tyrosine kinase 1,P62DOK, pp62
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DOK1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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