Human DENN domain-containing protein 5A (DENND5A) ELISA Kit
715€ (96 tests)
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935106861
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name
Human DENN domain-containing protein 5A (DENND5A) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx510104
tested applications
ELISA
Description
Human DENN domain-containing protein 5A (DENND5A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DENN domain-containing protein 5A (DENND5A) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DENN domain-containing protein 5A (DENND5A) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6IQ26 |
| Alias | DEE49,EIEE49,RAB6IP1,Rab6-interacting protein 1 |
| Background | Elisa kits for DENND5A |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DENN domain containing 5A (DENND5A) is a member of the DENN domain protein family, functioning as a guanine nucleotide exchange factor (GEF) for Rab GTPases, particularly Rab39. DENND5A plays a vital role in regulating endosomal trafficking, exocytosis, and lysosomal function by activating Rab39 through GDP-to-GTP exchange. This activity is critical for vesicular transport and recycling of proteins, such as receptors and ion channels, involved in signaling and nutrient uptake. DENND5A also contributes to autophagy by mediating the trafficking and fusion of autophagosomes and lysosomes, which are essential for the degradation of damaged organelles and proteins. It is expressed ubiquitously, with higher levels in tissues undergoing rapid turnover or high trafficking demands, such as neurons and epithelial cells. Dysregulation of DENND5A has been associated with neurological disorders and lysosomal storage diseases, where defects in vesicle transport disrupt cellular proteostasis and signaling pathways. Further research into its specific substrates and pathways may uncover additional roles in maintaining cellular health.
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