DENND5A Antibody (HRP)

Background

DENN domain containing 5A (DENND5A) is a member of the DENN domain protein family, functioning as a guanine nucleotide exchange factor (GEF) for Rab GTPases, particularly Rab39. DENND5A plays a vital role in regulating endosomal trafficking, exocytosis, and lysosomal function by activating Rab39 through GDP-to-GTP exchange. This activity is critical for vesicular transport and recycling of proteins, such as receptors and ion channels, involved in signaling and nutrient uptake. DENND5A also contributes to autophagy by mediating the trafficking and fusion of autophagosomes and lysosomes, which are essential for the degradation of damaged organelles and proteins. It is expressed ubiquitously, with higher levels in tissues undergoing rapid turnover or high trafficking demands, such as neurons and epithelial cells. Dysregulation of DENND5A has been associated with neurological disorders and lysosomal storage diseases, where defects in vesicle transport disrupt cellular proteostasis and signaling pathways. Further research into its specific substrates and pathways may uncover additional roles in maintaining cellular health.