DENN Domain-Containing Protein 5A (DENND5A) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
DENN Domain-Containing Protein 5A (DENND5A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx301449
tested applications
ELISA, IHC
Description
DENND5A Antibody is a Rabbit Polyclonal against DENND5A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DENN Domain-Containing Protein 5A (DENND5A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6IQ26 |
| Gene ID | 23258 |
| NCBI Accession | NP_001230183.1, NM_001243254.1, NP_001335677.1, NM_001348748.1 |
| OMIM | 617278 |
| Alias | DEE49,EIEE49,RAB6IP1,Rab6-interacting protein 1 |
| Background | Antibody anti-DENND5A |
| Status | RUO |
Descripción
DENN domain containing 5A (DENND5A) is a member of the DENN domain protein family, functioning as a guanine nucleotide exchange factor (GEF) for Rab GTPases, particularly Rab39. DENND5A plays a vital role in regulating endosomal trafficking, exocytosis, and lysosomal function by activating Rab39 through GDP-to-GTP exchange. This activity is critical for vesicular transport and recycling of proteins, such as receptors and ion channels, involved in signaling and nutrient uptake. DENND5A also contributes to autophagy by mediating the trafficking and fusion of autophagosomes and lysosomes, which are essential for the degradation of damaged organelles and proteins. It is expressed ubiquitously, with higher levels in tissues undergoing rapid turnover or high trafficking demands, such as neurons and epithelial cells. Dysregulation of DENND5A has been associated with neurological disorders and lysosomal storage diseases, where defects in vesicle transport disrupt cellular proteostasis and signaling pathways. Further research into its specific substrates and pathways may uncover additional roles in maintaining cellular health.
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