Human DENN Domain Containing Protein 3 (DENND3) ELISA Kit
715€ (96 tests)
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935106861
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name
Human DENN Domain Containing Protein 3 (DENND3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386856
tested applications
ELISA
Description
Human DENN Domain Containing Protein 3 (DENND3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DENND3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DENN Domain Containing Protein 3 (DENND3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | A2RUS2 |
| Gene ID | 22898 |
| OMIM | 617503 |
| Alias | KIAA0870 |
| Background | Elisa kits for DENND3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DENN domain containing 3 (DENND3) is a guanine nucleotide exchange factor (GEF) within the DENN domain protein family, specifically activating Rab GTPases such as Rab12. By facilitating the GDP-to-GTP exchange on Rab12, DENND3 regulates a range of critical cellular processes, including endosomal trafficking, lysosomal degradation, and autophagy. These functions are vital for maintaining intracellular protein turnover, as Rab12 is involved in protein sorting, vesicle transport, and the degradation of misfolded or unnecessary proteins through the autophagy-lysosome pathway. DENND3 also plays a role in cellular stress responses, where it modulates lysosomal activity to help cells adapt to metabolic or environmental challenges. It is broadly expressed across various tissues but is particularly active in cells with high endocytic demands, such as neurons and immune cells. Dysfunction or dysregulation of DENND3 has been associated with neurodegenerative diseases and disorders of cellular proteostasis, where defective lysosomal function can lead to the accumulation of cellular debris, contributing to neuronal and systemic damage.
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