DENND3 antibody
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935106861
info@markelab.com
name
DENND3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02333
tested applications
ELISA, WB
Description
Guanine nucleotide exchange factor(GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DENN/MADD domain containing 3 (DENND3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 136 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | A2RUS2 |
| Gene ID | 22898 |
| Alias | KIAA0870 |
| Background | Antibody anti-DENND3 |
| Status | RUO |
| Note | Mol. Weight 136 kDa |
Descripción
DENN domain containing 3 (DENND3) is a guanine nucleotide exchange factor (GEF) within the DENN domain protein family, specifically activating Rab GTPases such as Rab12. By facilitating the GDP-to-GTP exchange on Rab12, DENND3 regulates a range of critical cellular processes, including endosomal trafficking, lysosomal degradation, and autophagy. These functions are vital for maintaining intracellular protein turnover, as Rab12 is involved in protein sorting, vesicle transport, and the degradation of misfolded or unnecessary proteins through the autophagy-lysosome pathway. DENND3 also plays a role in cellular stress responses, where it modulates lysosomal activity to help cells adapt to metabolic or environmental challenges. It is broadly expressed across various tissues but is particularly active in cells with high endocytic demands, such as neurons and immune cells. Dysfunction or dysregulation of DENND3 has been associated with neurodegenerative diseases and disorders of cellular proteostasis, where defective lysosomal function can lead to the accumulation of cellular debris, contributing to neuronal and systemic damage.
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