DENN Domain Containing Protein 3 (DENND3) Antibody
364€ (100 µg)
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935106861
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name
DENN Domain Containing Protein 3 (DENND3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx232333
tested applications
ELISA, WB
Description
DENND3 Antibody is a Rabbit Polyclonal against DENND3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DENN Domain Containing Protein 3 (DENND3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A2RUS2 |
| Gene ID | 22898 |
| OMIM | 617503 |
| Alias | KIAA0870 |
| Background | Antibody anti-DENND3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
DENN domain containing 3 (DENND3) is a guanine nucleotide exchange factor (GEF) within the DENN domain protein family, specifically activating Rab GTPases such as Rab12. By facilitating the GDP-to-GTP exchange on Rab12, DENND3 regulates a range of critical cellular processes, including endosomal trafficking, lysosomal degradation, and autophagy. These functions are vital for maintaining intracellular protein turnover, as Rab12 is involved in protein sorting, vesicle transport, and the degradation of misfolded or unnecessary proteins through the autophagy-lysosome pathway. DENND3 also plays a role in cellular stress responses, where it modulates lysosomal activity to help cells adapt to metabolic or environmental challenges. It is broadly expressed across various tissues but is particularly active in cells with high endocytic demands, such as neurons and immune cells. Dysfunction or dysregulation of DENND3 has been associated with neurodegenerative diseases and disorders of cellular proteostasis, where defective lysosomal function can lead to the accumulation of cellular debris, contributing to neuronal and systemic damage.
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