Human Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx537540
tested applications
ELISA
Description
Human Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.16 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P54886 |
| Gene ID | 5832 |
| Alias | P5CS,Aldehyde dehydrogenase family 18 member A1 |
| Background | Elisa Kits for: ALDH18A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
ALDH18A1, also known as P5CS (pyrroline-5-carboxylate synthase), is a mitochondrial enzyme that catalyzes the conversion of glutamate into pyrroline-5-carboxylate (P5C), a key step in proline and ornithine biosynthesis. This enzyme is crucial for amino acid metabolism, cellular redox balance, and collagen synthesis. ALDH18A1 is highly expressed in tissues with high metabolic activity, such as the liver, kidney, and brain. Mutations in ALDH18A1 are linked to autosomal dominant and recessive forms of P5CS deficiency, which result in hyperammonemia, intellectual disability, and connective tissue disorders due to impaired proline biosynthesis. ALDH18A1 dysfunction also contributes to neurodegenerative diseases and metabolic syndromes by disrupting amino acid metabolism and cellular stress responses. Its role in collagen synthesis makes ALDH18A1 essential for proper skin, bone, and connective tissue maintenance, and it is actively studied for its involvement in aging and fibrosis.
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ALDH18A1 Antibody is a Rabbit Polyclonal antibody against ALDH18A1. This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
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