Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1) Antibody
637€ (100 µl)
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935106861
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name
Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110914
tested applications
ELISA, WB
Description
Aldehyde Dehydrogenase 18 Family, Member A1 Antibody is a Rabbit Polyclonal antibody against Aldehyde Dehydrogenase 18 Family, Member A1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54886 |
| Gene ID | 5832 |
| NCBI Accession | NP_001017423.1, NM_001017423.1, NP_001310341.1, NM_001323412.1, NP_001310342.1, NM_001323413.1 |
| OMIM | 138250 |
| Alias | P5CS,Aldehyde dehydrogenase family 18 member A1 |
| Background | Antibody anti-ALDH18A1 |
| Status | RUO |
Descripción
ALDH18A1, also known as P5CS (pyrroline-5-carboxylate synthase), is a mitochondrial enzyme that catalyzes the conversion of glutamate into pyrroline-5-carboxylate (P5C), a key step in proline and ornithine biosynthesis. This enzyme is crucial for amino acid metabolism, cellular redox balance, and collagen synthesis. ALDH18A1 is highly expressed in tissues with high metabolic activity, such as the liver, kidney, and brain. Mutations in ALDH18A1 are linked to autosomal dominant and recessive forms of P5CS deficiency, which result in hyperammonemia, intellectual disability, and connective tissue disorders due to impaired proline biosynthesis. ALDH18A1 dysfunction also contributes to neurodegenerative diseases and metabolic syndromes by disrupting amino acid metabolism and cellular stress responses. Its role in collagen synthesis makes ALDH18A1 essential for proper skin, bone, and connective tissue maintenance, and it is actively studied for its involvement in aging and fibrosis.
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