Delta-1-Pyrroline-5-Carboxylate Synthase (ALDH18A) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Delta-1-Pyrroline-5-Carboxylate Synthase (ALDH18A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037213
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the ALDH18A protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Delta-1-Pyrroline-5-Carboxylate Synthase (ALDH18A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | P5CS,Aldehyde dehydrogenase family 18 member A1 |
| Background | Antibody anti-ALDH18A1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ALDH18A1, also known as P5CS (pyrroline-5-carboxylate synthase), is a mitochondrial enzyme that catalyzes the conversion of glutamate into pyrroline-5-carboxylate (P5C), a key step in proline and ornithine biosynthesis. This enzyme is crucial for amino acid metabolism, cellular redox balance, and collagen synthesis. ALDH18A1 is highly expressed in tissues with high metabolic activity, such as the liver, kidney, and brain. Mutations in ALDH18A1 are linked to autosomal dominant and recessive forms of P5CS deficiency, which result in hyperammonemia, intellectual disability, and connective tissue disorders due to impaired proline biosynthesis. ALDH18A1 dysfunction also contributes to neurodegenerative diseases and metabolic syndromes by disrupting amino acid metabolism and cellular stress responses. Its role in collagen synthesis makes ALDH18A1 essential for proper skin, bone, and connective tissue maintenance, and it is actively studied for its involvement in aging and fibrosis.
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