Human Dedicator Of Cytokinesis Protein 6 (DOCK6) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Dedicator Of Cytokinesis Protein 6 (DOCK6) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386963
tested applications
ELISA
Description
Human Dedicator Of Cytokinesis Protein 6 (DOCK6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DOCK6 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Dedicator Of Cytokinesis Protein 6 (DOCK6) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.1 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96HP0 |
| Gene ID | 57572 |
| OMIM | 614194 |
| Alias | DOCK6, KIAA1395,AOS2, ZIR1 |
| Background | Elisa kits for DOCK6 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DOCK6 is a dual GEF for Rac1 and Cdc42, critical for cytoskeleton regulation, neurite outgrowth, and axonal growth. It facilitates actin and microtubule dynamics, influencing processes like neuronal development and fibroblast migration. DOCK6 mutations are associated with Adams-Oliver syndrome, characterized by limb and scalp defects due to impaired cell migration. It is expressed in neural and connective tissues, where it regulates cellular polarity and adhesion. DOCK6 interacts with Rac1 to drive membrane protrusion and lamellipodia formation. Knockdown studies show defects in axonal elongation and cellular migration, underscoring its role in tissue development and repair.
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