Docking Protein 6 (DOCK6) Antibody (HRP)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Docking Protein 6 (DOCK6) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx313730
tested applications
ELISA
Description
DOCK6 Antibody (HRP) is a Rabbit Polyclonal against DOCK6 conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 6 (DOCK6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96HP0 |
| Gene ID | 57572 |
| OMIM | 614194 |
| Alias | DOCK6, KIAA1395,AOS2, ZIR1 |
| Background | Antibody anti-DOCK6 |
| Status | RUO |
Descripción
DOCK6 is a dual GEF for Rac1 and Cdc42, critical for cytoskeleton regulation, neurite outgrowth, and axonal growth. It facilitates actin and microtubule dynamics, influencing processes like neuronal development and fibroblast migration. DOCK6 mutations are associated with Adams-Oliver syndrome, characterized by limb and scalp defects due to impaired cell migration. It is expressed in neural and connective tissues, where it regulates cellular polarity and adhesion. DOCK6 interacts with Rac1 to drive membrane protrusion and lamellipodia formation. Knockdown studies show defects in axonal elongation and cellular migration, underscoring its role in tissue development and repair.
Related Products
anti- DOCK6 antibody
Acts as guanine nucleotide exchange factor(GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth(By similarity).
Ver Producto
Recombinant Human DOCK6
Ver Producto