anti- DOCK4 antibody
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935106861
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name
anti- DOCK4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02495
tested applications
ELISA, IP, IHC
Description
Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor(GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | dedicator of cytokinesis 4 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 225 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IP, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8N1I0 |
| Gene ID | 9732 |
| Alias | DOCK4, KIAA0716 |
| Background | Antibody anti-DOCK4 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
DOCK4 is a GEF that activates Rac1 and Rap1, regulating cell adhesion, migration, and junction formation. It is critical for maintaining epithelial integrity and angiogenesis by promoting actin cytoskeletal remodeling. DOCK4 is widely expressed in tissues, including the brain, and has roles in neuronal development, synapse formation, and dendritic growth. Mutations in DOCK4 are linked to cancers, particularly prostate, ovarian, and colorectal cancers, as they disrupt cell adhesion and enhance invasion. It interacts with proteins like ELMO1 for Rac1 activation and mediates processes such as cell spreading. Knockdown studies show impaired junction stability and migration, emphasizing its role in tissue organization and metastasis.
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