Human DDB1- and CUL4-associated factor 17 (DCAF17) ELISA Kit

Background

DDB1 and CUL4 associated factor 17 (DCAF17) is a substrate receptor of the CUL4-DDB1 E3 ubiquitin ligase complex, involved in the regulation of protein ubiquitination and degradation. DCAF17 contains WD40 repeats, which mediate protein-protein interactions and the recognition of specific substrates for targeted degradation. Its expression pattern suggests roles in various tissues, particularly in processes related to cellular homeostasis and proteostasis. DCAF17 has been implicated in nuclear and cytoplasmic functions, including the maintenance of protein quality and the regulation of signaling pathways. Genetic studies indicate that DCAF17 may be involved in developmental processes, as mutations in its gene have been associated with craniofacial abnormalities and intellectual disability. The precise substrates and mechanisms of DCAF17's action remain areas of active investigation, but its role in the ubiquitin-proteasome system highlights its importance in maintaining cellular function and response to environmental stress.