Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein
247€ (10 µg)
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name
Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652192
tested applications
WB, SDS-PAGE
Description
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein is a Recombinant protein from Human.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 68.1 kDa Observed MW (SDS-PAGE): 68 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Gly330 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13569 |
| Alias | ATP-binding cassette sub-family C member 7,CF,MRP7,ABC35,ABCC7,CFTR/MRP,TNR-CFTR,dJ760C5.1,Cystic fibrosis transmembrane conductance regulator,Channel conductance-controlling ATPase |
| Background | Protein CFTR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CF Transmembrane Conductance Regulator (ABCC7), widely known as the cystic fibrosis transmembrane conductance regulator (CFTR), is a chloride channel essential for maintaining ion and water balance across epithelial cell membranes. Mutations in the CFTR gene cause cystic fibrosis (CF), a life-threatening genetic disorder that leads to thick mucus buildup in the lungs, pancreas, and other organs. As an ATP-gated channel, ABCC7 regulates chloride and bicarbonate secretion, influencing fluid viscosity and pH in various tissues. Beyond ion transport, CFTR modulates inflammation and immune responses, contributing to its broader physiological significance. Therapeutic interventions targeting CFTR, such as small-molecule modulators, have revolutionized CF management, improving lung function and quality of life for many patients. Additionally, CFTR dysfunction has been implicated in other conditions like chronic obstructive pulmonary disease (COPD) and pancreatitis, underlining its relevance in diverse respiratory and gastrointestinal diseases.
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