Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) CLIA Kit
643.5€ (96 tests)
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name
Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196585
tested applications
CLIA
Description
Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | 18.8 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ATP-binding cassette sub-family C member 7,CF,MRP7,ABC35,ABCC7,CFTR/MRP,TNR-CFTR,dJ760C5.1,Cystic fibrosis transmembrane conductance regulator,Channel conductance-controlling ATPase |
| Background | CLIA Kits CFTR |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CF Transmembrane Conductance Regulator (ABCC7), widely known as the cystic fibrosis transmembrane conductance regulator (CFTR), is a chloride channel essential for maintaining ion and water balance across epithelial cell membranes. Mutations in the CFTR gene cause cystic fibrosis (CF), a life-threatening genetic disorder that leads to thick mucus buildup in the lungs, pancreas, and other organs. As an ATP-gated channel, ABCC7 regulates chloride and bicarbonate secretion, influencing fluid viscosity and pH in various tissues. Beyond ion transport, CFTR modulates inflammation and immune responses, contributing to its broader physiological significance. Therapeutic interventions targeting CFTR, such as small-molecule modulators, have revolutionized CF management, improving lung function and quality of life for many patients. Additionally, CFTR dysfunction has been implicated in other conditions like chronic obstructive pulmonary disease (COPD) and pancreatitis, underlining its relevance in diverse respiratory and gastrointestinal diseases.
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