Human Corticotropin Releasing Hormone Receptor 2 (CRHR2) Protein

Product specifications

Proteins and Peptides

Corticotropin Releasing Hormone Receptor 2 (CRHR2)

E. coli

Human

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

CRHR2,CRFR2,CRF-R2,CRH-R2,CRF 2 receptor,CRFR2alpha,CRFR2beta,CRF2,CRF-RB,HM-CRF

Protein CRHR2

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CRHR2 is a G protein-coupled receptor that binds CRH and urocortins (urocortin 2 and urocortin 3), with roles in modulating stress responses, cardiovascular function, and energy homeostasis. CRHR2 is expressed in peripheral tissues, including the heart, gastrointestinal tract, and vasculature, as well as in specific brain regions such as the hypothalamus and brainstem. Unlike CRHR1, CRHR2 is more involved in stress recovery and adaptation, mediating anti-stress effects by regulating heart rate, vascular tone, and feeding behaviors. CRHR2 activation triggers signaling pathways such as cAMP/PKA and MAPK, which regulate cell proliferation, relaxation of smooth muscle, and metabolic homeostasis. It plays a protective role in cardiovascular function, where its activation reduces blood pressure and cardiac stress. CRHR2 is also involved in regulating appetite suppression and energy expenditure, making it a potential target for obesity and metabolic disorders. Dysregulation of CRHR2 has been linked to stress-related disorders, heart disease, and gastrointestinal dysfunction. In cancer, CRHR2 may modulate tumor progression through its effects on angiogenesis and stress pathways. CRHR2 agonists and antagonists are under investigation for their therapeutic potential in cardiovascular disease, metabolic dysfunctions, and stress-related psychiatric disorders, highlighting its role in recovery from physiological and psychological stress.

Related Products

Human CRHR2(Corticotropin-releasing factor receptor 2) ELISA Kit

Ver Producto

Rat Crhr2(Corticotropin-releasing factor receptor 2) ELISA Kit

Ver Producto

anti- CRHR2 antibody

G-protein coupled receptor for CRH(corticotropin-releasing factor), UCN(urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins(G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Ver Producto