Corticotropin Releasing Hormone Receptor 2 (CRHR2) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Corticotropin Releasing Hormone Receptor 2 (CRHR2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx032984
Tested Applications
ELISA, WB, IHC, IF/ICC, FCM
Description
CRHR2 is a receptor for corticotropin releasing factor.It Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Corticotropin Releasing Hormone Receptor 2 (CRHR2) Immunogen: KLH-conjugated synthetic peptide between 243-272 amino acids from the Central region of human CRHR2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 47.7 kDa |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13324 |
| Alias | CRHR2,CRFR2,CRF-R2,CRH-R2,CRF 2 receptor,CRFR2alpha,CRFR2beta,CRF2,CRF-RB,HM-CRF |
| Background | Antibody anti-CRHR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CRHR2 is a G protein-coupled receptor that binds CRH and urocortins (urocortin 2 and urocortin 3), with roles in modulating stress responses, cardiovascular function, and energy homeostasis. CRHR2 is expressed in peripheral tissues, including the heart, gastrointestinal tract, and vasculature, as well as in specific brain regions such as the hypothalamus and brainstem. Unlike CRHR1, CRHR2 is more involved in stress recovery and adaptation, mediating anti-stress effects by regulating heart rate, vascular tone, and feeding behaviors. CRHR2 activation triggers signaling pathways such as cAMP/PKA and MAPK, which regulate cell proliferation, relaxation of smooth muscle, and metabolic homeostasis. It plays a protective role in cardiovascular function, where its activation reduces blood pressure and cardiac stress. CRHR2 is also involved in regulating appetite suppression and energy expenditure, making it a potential target for obesity and metabolic disorders. Dysregulation of CRHR2 has been linked to stress-related disorders, heart disease, and gastrointestinal dysfunction. In cancer, CRHR2 may modulate tumor progression through its effects on angiogenesis and stress pathways. CRHR2 agonists and antagonists are under investigation for their therapeutic potential in cardiovascular disease, metabolic dysfunctions, and stress-related psychiatric disorders, highlighting its role in recovery from physiological and psychological stress.
Productos relacionados
Corticotropin Releasing Hormone Receptor 2 (CRHR2) Antibody
CRHR2 is a receptor for corticotropin releasing factor.It Shows high-affinity CRF binding. Also binds to urocortin I, II…
Ver producto Corticotropin Releasing Hormone Receptor 2 (CRHR2) Antibody
CRHR2 is a receptor for corticotropin releasing factor.It Shows high-affinity CRF binding. Also binds to urocortin I, II…
Ver producto
Human Corticotropin Releasing Hormone Receptor 2 (CRHR2) ELISA Kit
Human Corticotropin Releasing Hormone Receptor 2 (CRHR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measure…
Ver producto