Human Complement C5a (C5a) Protein

Este producto es parte de Complement C5
Human Complement C5a (C5a) Protein

Pida mas información

935106861

info@markelab.com

Precio

741€ (50 µg)

Protein C5

proveedor

Abbexa

reference

abx651317

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Complement Component 5a (C5a) Protein (Active) is an active protein from Human.


Background

C5 is a central component of the complement system and plays a key role in the final steps of the complement cascade C5 is cleaved into C5a and C5b, with C5a acting as a potent inflammatory mediator that recruits immune cells to sites of infection or injury, and C5b contributing to the formation of the membrane attack complex (MAC), which leads to the lysis of pathogens C5 is involved in both innate and adaptive immune responses, helping to clear pathogens, regulate inflammation, and promote tissue repair Dysfunction in C5 or its components is associated with several diseases, including complement deficiencies, where insufficient activation leads to increased susceptibility to infections, and autoimmune disorders like atypical hemolytic uremic syndrome (aHUS) Studies also suggest that C5 plays a role in cancer progression, where its activity can influence immune evasion and tumor microenvironment regulation

Características del producto

category

Proteins and Peptides


origin

Human


host

293F cell


immunogen target

Complement C5a (C5a)


host

293F cell


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 35.0 kDa Observed MW: 35 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr678-Arg751 Tag: N-terminal His tag


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

C5


dry ice

No


availability

Shipped within 5-7 working days.


alias

C5D,C5a,C5b,ECLZB,CPAMD4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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