Human Complement C5a (C5a) Protein

Este producto es parte de Complement C5
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741€ (50 µg)

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935106861
info@markelab.com
name
Human Complement C5a (C5a) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx651317
tested applications
WB, SDS-PAGE

Description

Complement Component 5a (C5a) Protein (Active) is an active protein from Human.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Complement C5a (C5a)
Host
293F cell
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 35.0 kDa  Observed MW: 35 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Thr678-Arg751
Tag: N-terminal His tag
Purity
> 95%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P01031
Alias
C5D,C5a,C5b,ECLZB,CPAMD4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Background
Protein C5
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

C5 is a central component of the complement system and plays a key role in the final steps of the complement cascade C5 is cleaved into C5a and C5b, with C5a acting as a potent inflammatory mediator that recruits immune cells to sites of infection or injury, and C5b contributing to the formation of the membrane attack complex (MAC), which leads to the lysis of pathogens C5 is involved in both innate and adaptive immune responses, helping to clear pathogens, regulate inflammation, and promote tissue repair Dysfunction in C5 or its components is associated with several diseases, including complement deficiencies, where insufficient activation leads to increased susceptibility to infections, and autoimmune disorders like atypical hemolytic uremic syndrome (aHUS) Studies also suggest that C5 plays a role in cancer progression, where its activity can influence immune evasion and tumor microenvironment regulation

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