Complement C5 (C5) Antibody
292.5€ (80 µl)
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name
Complement C5 (C5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034006
tested applications
ELISA, WB, IHC, FCM
Description
C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Complement C5 (C5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01031 |
| Gene ID | 727 |
| OMIM | 120900 |
| Alias | C5D,C5a,C5b,ECLZB,CPAMD4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
| Background | Antibody anti-C5 |
| Status | RUO |
Descripción
C5 is a central component of the complement system and plays a key role in the final steps of the complement cascade C5 is cleaved into C5a and C5b, with C5a acting as a potent inflammatory mediator that recruits immune cells to sites of infection or injury, and C5b contributing to the formation of the membrane attack complex (MAC), which leads to the lysis of pathogens C5 is involved in both innate and adaptive immune responses, helping to clear pathogens, regulate inflammation, and promote tissue repair Dysfunction in C5 or its components is associated with several diseases, including complement deficiencies, where insufficient activation leads to increased susceptibility to infections, and autoimmune disorders like atypical hemolytic uremic syndrome (aHUS) Studies also suggest that C5 plays a role in cancer progression, where its activity can influence immune evasion and tumor microenvironment regulation
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