Human Cleavage Stimulation Factor Subunit 1 (CSTF1) Protein
234€ (2 µg)
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Name
Human Cleavage Stimulation Factor Subunit 1 (CSTF1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx680431
Tested Applications
SDS-PAGE
Description
Human Cleavage Stimulation Factor Subunit 1 (CSTF1) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Cleavage Stimulation Factor Subunit 1 (CSTF1) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | CstF-50,CstFp50,CF-1 50 kDa subunit,Cleavage stimulation factor 50 kDa subunit |
| Background | Protein CSTF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Cleavage stimulation factor subunit 1 (CSTF1) is a component of the cleavage stimulation factor (CstF) complex, which is crucial for the polyadenylation and 3' end cleavage of pre-mRNAs. CSTF1 contains transducin-like WD40 repeats and functions as a homodimer within the CstF complex. It interacts directly with CSTF2 and CSTF3 to form the heterotrimeric CstF complex, which assembles on the pre-mRNA to facilitate cleavage and subsequent polyadenylation. CSTF1 is responsible for mediating interactions between CstF and other factors, ensuring the formation of a stable complex on the pre-mRNA. The expression levels of CstF components, including CSTF1, vary during the cell cycle, increasing significantly during the transition from G0 to S phase, indicating a role in cell cycle-regulated mRNA processing. Additionally, CSTF1 has been shown to interact with BARD1, linking mRNA 3' end formation to DNA damage response and tumor suppression pathways.
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