Human Chemokine C-X-C-Motif Receptor 6 (CXCR6) Peptide (OVA)
442€ (100 µg)
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935106861
info@markelab.com
name
Human Chemokine C-X-C-Motif Receptor 6 (CXCR6) Peptide (OVA)
category
Proteins and Peptides
provider
Abbexa
reference
abx651258
tested applications
WB, SDS-PAGE
Description
CXCR6 Peptide (OVA) is a Human protein conjugated to OVA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Chemokine C-X-C-Motif Receptor 6 (CXCR6) |
| Origin | Human |
| Conjugation | OVA |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys319-Ser338 |
| Expression | Synthetic |
| Purity | > 90% |
| Size 1 | 100 µg |
| Size 2 | 200 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Size 5 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CXCR6,BONZO,CD186,CDw186,STRL33,TYMSTR |
| Background | Protein CXCR6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CXCR6 is a G protein-coupled receptor primarily expressed on T cells, natural killer T (NKT) cells, and some epithelial and endothelial cells. It binds its unique ligand CXCL16, which exists as both a soluble and membrane-bound form, facilitating cell adhesion and migration. CXCR6 plays a key role in T cell homing to inflamed tissues and tumor microenvironments, as well as in the maintenance of resident memory T cells. Inflammatory diseases such as rheumatoid arthritis, atherosclerosis, and liver fibrosis are associated with CXCR6-mediated immune cell recruitment. In cancer, CXCR6 expression is elevated in tumor-infiltrating lymphocytes and cancer cells, where CXCL16-CXCR6 signaling promotes cell adhesion, migration, and tumor progression. It has been implicated in prostate, breast, and lung cancers, enhancing metastasis to specific organs like the liver. CXCR6 also contributes to chronic viral infections, such as HIV and hepatitis, by directing immune cells to persistently infected tissues. Its signaling activates pathways like PI3K and MAPK, promoting cell survival and proliferation. CXCR6 is important for immune surveillance but, when dysregulated, supports chronic inflammation and disease progression, positioning it as a target for therapies in inflammation, cancer, and viral infections.
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