Chemokine C-X-C-Motif Receptor 6 (CXCR6) Antibody

Este producto es parte de CXCR - C-X-C motif chemokine receptor
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Chemokine C-X-C-Motif Receptor 6 (CXCR6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx027326
tested applications
ELISA, WB

Description

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Chemokine C-X-C-Motif Receptor 6 (CXCR6)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O00574
Alias
CXCR6,BONZO,CD186,CDw186,STRL33,TYMSTR
Background
Antibody anti-CXCR6
Status
RUO

Descripción

CXCR6 is a G protein-coupled receptor primarily expressed on T cells, natural killer T (NKT) cells, and some epithelial and endothelial cells. It binds its unique ligand CXCL16, which exists as both a soluble and membrane-bound form, facilitating cell adhesion and migration. CXCR6 plays a key role in T cell homing to inflamed tissues and tumor microenvironments, as well as in the maintenance of resident memory T cells. Inflammatory diseases such as rheumatoid arthritis, atherosclerosis, and liver fibrosis are associated with CXCR6-mediated immune cell recruitment. In cancer, CXCR6 expression is elevated in tumor-infiltrating lymphocytes and cancer cells, where CXCL16-CXCR6 signaling promotes cell adhesion, migration, and tumor progression. It has been implicated in prostate, breast, and lung cancers, enhancing metastasis to specific organs like the liver. CXCR6 also contributes to chronic viral infections, such as HIV and hepatitis, by directing immune cells to persistently infected tissues. Its signaling activates pathways like PI3K and MAPK, promoting cell survival and proliferation. CXCR6 is important for immune surveillance but, when dysregulated, supports chronic inflammation and disease progression, positioning it as a target for therapies in inflammation, cancer, and viral infections.

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abx027326

Chemokine C-X-C-Motif Receptor 6 (CXCR6) Antibody

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Ver Producto