Human C-Type Lectin Domain Family 4, Member M (CLEC4M) Protein
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Description
Human C-Type Lectin Domain Family 4, Member M (CLEC4M) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | C-Type Lectin Domain Family 4, Member M (CLEC4M) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 22.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro242-Glu399 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H2X3 |
| Alias | C-type lectin domain family 4 member M,CD299,LSIGN,CD209L,L-SIGN,DCSIGNR,HP10347,DC-SIGN2,DC-SIGNR,DC-SIGN-related protein,Dendritic cell-specific ICAM-3-grabbing non-integrin 2 |
| Background | Protein CLEC4M |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CLEC4M (C-type lectin domain family 4 member M), also known as L-SIGN (liver/lymph node-specific ICAM-3 grabbing non-integrin), is a member of the C-type lectin receptor family that primarily functions as a carbohydrate-binding receptor on endothelial cells. CLEC4M is highly expressed on sinusoidal endothelial cells, particularly in the liver and lymph nodes. This receptor is involved in pathogen recognition and immune response modulation, functioning in cellular adhesion and interactions with a variety of pathogens through specific carbohydrate binding. CLEC4M plays a role in the immune system’s surveillance of pathogens and in mediating interactions with viruses, bacteria, and other infectious agents, particularly in tissues involved in blood filtration and immune processing. CLEC4M has garnered significant interest due to its ability to bind to glycosylated molecules on pathogens, such as viruses like SARS-CoV, HIV-1, and hepatitis C, contributing to viral capture and cellular entry. Additionally, it can act as a trans-infection receptor, where it captures viruses on non-permissive cells, which are then transferred to permissive cells to facilitate viral replication. Thus, CLEC4M’s role in pathogen recognition and immune response regulation is crucial to both its physiological function and its involvement in disease.
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Human CLEC4M (C-type lectin domain family 4 member M) ELISA Kit
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CLEC4M antibody
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for ebola virus(PubMed:12050398, PubMed:12502850). Acts as an attachment receptor for hepatitis C virus(PubMed:15371595, PubMed:16816373). Acts as an attachment receptor for HIV-1(PubMed:21277928, PubMed:12502850). Acts as an attachment receptor for human coronavirus 229E(PubMed:17037540). Acts as an attachment receptor for human cytomegalovirus/HHV-5(PubMed:12433371). Acts as an attachment receptor for influenzavirus(PubMed:21191006). Acts as an attachment receptor for SARS coronavirus(PubMed:15479853). Acts as an attachment receptor for west-nile virus(PubMed:16415006). Acts as an attachment receptor for Japanese encephalitis virus(PubMed:24623090). Acts as an attachment receptor for Marburg virus glycoprotein(PubMed:15479853). Recognition of M.bovis by dendritic cells may occur partially via this molecule(PubMed:21203928).
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