C-Type Lectin Domain Family 4, Member M (CLEC4M) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
C-Type Lectin Domain Family 4, Member M (CLEC4M) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104154
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: C-Type Lectin Domain Family 4, Member M (CLEC4M) Immunogen: abx066171 - Recombinant CLEC4M (Pro242-Glu399) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | C-type lectin domain family 4 member M,CD299,LSIGN,CD209L,L-SIGN,DCSIGNR,HP10347,DC-SIGN2,DC-SIGNR,DC-SIGN-related protein,Dendritic cell-specific ICAM-3-grabbing non-integrin 2 |
| Background | Antibody anti-CLEC4M |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
CLEC4M (C-type lectin domain family 4 member M), also known as L-SIGN (liver/lymph node-specific ICAM-3 grabbing non-integrin), is a member of the C-type lectin receptor family that primarily functions as a carbohydrate-binding receptor on endothelial cells. CLEC4M is highly expressed on sinusoidal endothelial cells, particularly in the liver and lymph nodes. This receptor is involved in pathogen recognition and immune response modulation, functioning in cellular adhesion and interactions with a variety of pathogens through specific carbohydrate binding. CLEC4M plays a role in the immune system’s surveillance of pathogens and in mediating interactions with viruses, bacteria, and other infectious agents, particularly in tissues involved in blood filtration and immune processing. CLEC4M has garnered significant interest due to its ability to bind to glycosylated molecules on pathogens, such as viruses like SARS-CoV, HIV-1, and hepatitis C, contributing to viral capture and cellular entry. Additionally, it can act as a trans-infection receptor, where it captures viruses on non-permissive cells, which are then transferred to permissive cells to facilitate viral replication. Thus, CLEC4M’s role in pathogen recognition and immune response regulation is crucial to both its physiological function and its involvement in disease.
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Human C-Type Lectin Domain Family 4, Member M (CLEC4M) Protein
Human C-Type Lectin Domain Family 4, Member M (CLEC4M) is a recombinant Human protein expressed in E. coli.
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