Human C-Type Lectin Domain Family 4 Member M (CLEC4M) ELISA Kit

Este producto es parte de CLEC4M - C-type lectin domain family 4 member M
Human C-Type Lectin Domain Family 4 Member M (CLEC4M) ELISA Kit
715€ (96 tests)

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Name
Human C-Type Lectin Domain Family 4 Member M (CLEC4M) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx386568
Tested Applications
ELISA

Description

Human C-Type Lectin Domain Family 4 Member M (CLEC4M) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human CLEC4M concentrations in serum, plasma and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
C-Type Lectin Domain Family 4 Member M (CLEC4M)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
3.12 ng/ml - 200 ng/ml
Sensitivity
< 1.88 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9H2X3
Gene ID
10332
OMIM
605872
Alias
C-type lectin domain family 4 member M,CD299,LSIGN,CD209L,L-SIGN,DCSIGNR,HP10347,DC-SIGN2,DC-SIGNR,DC-SIGN-related protein,Dendritic cell-specific ICAM-3-grabbing non-integrin 2
Background
Elisa Kits for: CLEC4M
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

CLEC4M (C-type lectin domain family 4 member M), also known as L-SIGN (liver/lymph node-specific ICAM-3 grabbing non-integrin), is a member of the C-type lectin receptor family that primarily functions as a carbohydrate-binding receptor on endothelial cells. CLEC4M is highly expressed on sinusoidal endothelial cells, particularly in the liver and lymph nodes. This receptor is involved in pathogen recognition and immune response modulation, functioning in cellular adhesion and interactions with a variety of pathogens through specific carbohydrate binding. CLEC4M plays a role in the immune system’s surveillance of pathogens and in mediating interactions with viruses, bacteria, and other infectious agents, particularly in tissues involved in blood filtration and immune processing. CLEC4M has garnered significant interest due to its ability to bind to glycosylated molecules on pathogens, such as viruses like SARS-CoV, HIV-1, and hepatitis C, contributing to viral capture and cellular entry. Additionally, it can act as a trans-infection receptor, where it captures viruses on non-permissive cells, which are then transferred to permissive cells to facilitate viral replication. Thus, CLEC4M’s role in pathogen recognition and immune response regulation is crucial to both its physiological function and its involvement in disease.

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