Human C-Type Lectin Domain Family 4, Member C (CLEC4C) Protein

Name: Human C-Type Lectin Domain Family 4, Member C (CLEC4C) Protein
Brand: Abbexa
SKU: abx066170
Price: 234 EUR
Availability: OnlineOnly

Este producto es parte de CLEC4C - C-type lectin domain family 4 member C

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein CLEC4C

proveedor

Abbexa

reference

abx066170

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant C-Type Lectin Domain Family 4, Member C (CLEC4C) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Background

CLEC4C, also known as CD303 or BDCA-2 (Blood Dendritic Cell Antigen 2), is a member of the C-type lectin domain family 4 of receptors and is highly specific to plasmacytoid dendritic cells (pDCs), a subset of immune cells that are crucial for antiviral responses. CLEC4C serves as a pattern recognition receptor (PRR), identifying and binding to carbohydrate structures on pathogens, which helps initiate immune responses. Unlike many other C-type lectins that are broadly expressed on various immune cells, CLEC4C is primarily expressed on pDCs, a unique cell type specializing in the secretion of large quantities of type I interferons (IFN-α/β) in response to viral infections. This exclusive expression gives CLEC4C a unique role in the immune system, particularly in antiviral defense and modulating immune responses in both innate and adaptive immunity. CLEC4C is involved in immune modulation by inhibiting type I interferon production when cross-linked, adding another layer to immune regulation. It is studied extensively in the context of autoimmune diseases and chronic infections because of its involvement in pDC-mediated responses. Furthermore, its specific expression on pDCs has made CLEC4C a target for therapeutic interventions aimed at modulating pDC activity in autoimmune diseases and certain cancers.

Características del producto

origin

Human

host

E. coli

immunogen target

C-Type Lectin Domain Family 4, Member C (CLEC4C)

host

E. coli

conjugation

Unconjugated

form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

tested applications

WB, SDS-PAGE

size 1

10 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

500 µg

observerd MW

Molecular Weight: Calculated MW: 24.7 kDa Observed MW (SDS-PAGE): 25 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu5-Ile183 Tag: N-terminal His tag

expression

Recombinant

purity

> 97%

buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.

storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

or code

CLEC4C

dry ice

availability

Shipped within 5-7 working days.

alias

C-type lectin domain family 4 member C,DLEC,HECL,BDCA2,CD303,BDCA-2,CLECSF7,CLECSF11,Blood dendritic cell antigen 2,Dendritic lectin

uniprot id

https://www.uniprot.org/uniprotkb/Q8WTT0

note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Quizá le pueda interesar

anti- CLEC4C antibody

proveedor

FineTest

reference

FNab01753

Tested Applications

ELISA

reactivity

human

status

RUO

clonality

polyclonal

Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation t...

Precio a consultar