Human C-Type Lectin Domain Family 4, Member C (CLEC4C) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human C-Type Lectin Domain Family 4, Member C (CLEC4C) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx066170
tested applications
WB, SDS-PAGE
Description
Recombinant C-Type Lectin Domain Family 4, Member C (CLEC4C) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | C-Type Lectin Domain Family 4, Member C (CLEC4C) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 24.7 kDa Observed MW (SDS-PAGE): 25 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu5-Ile183 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WTT0 |
| Alias | C-type lectin domain family 4 member C,DLEC,HECL,BDCA2,CD303,BDCA-2,CLECSF7,CLECSF11,Blood dendritic cell antigen 2,Dendritic lectin |
| Background | Protein CLEC4C |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CLEC4C, also known as CD303 or BDCA-2 (Blood Dendritic Cell Antigen 2), is a member of the C-type lectin domain family 4 of receptors and is highly specific to plasmacytoid dendritic cells (pDCs), a subset of immune cells that are crucial for antiviral responses. CLEC4C serves as a pattern recognition receptor (PRR), identifying and binding to carbohydrate structures on pathogens, which helps initiate immune responses. Unlike many other C-type lectins that are broadly expressed on various immune cells, CLEC4C is primarily expressed on pDCs, a unique cell type specializing in the secretion of large quantities of type I interferons (IFN-α/β) in response to viral infections. This exclusive expression gives CLEC4C a unique role in the immune system, particularly in antiviral defense and modulating immune responses in both innate and adaptive immunity. CLEC4C is involved in immune modulation by inhibiting type I interferon production when cross-linked, adding another layer to immune regulation. It is studied extensively in the context of autoimmune diseases and chronic infections because of its involvement in pDC-mediated responses. Furthermore, its specific expression on pDCs has made CLEC4C a target for therapeutic interventions aimed at modulating pDC activity in autoimmune diseases and certain cancers.
Related Products
anti- CLEC4C antibody
Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.
Ver Producto
Human C-Type Lectin Domain Family 4, Member C (CLEC4C) Protein
Recombinant C-Type Lectin Domain Family 4, Member C (CLEC4C) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver Producto
C-Type Lectin Domain Family 4, Member C (CLEC4C) Antibody
Polyclonal Antibody to C-Type Lectin Domain Family 4, Member C (CLEC4C).
Ver Producto