Family main features
CLEC4C, also known as CD303 or BDCA-2 (Blood Dendritic Cell Antigen 2), is a member of the C-type lectin domain family 4 of receptors and is highly specific to plasmacytoid dendritic cells (pDCs), a subset of immune cells that are crucial for antiviral responses. CLEC4C serves as a pattern recognition receptor (PRR), identifying and binding to carbohydrate structures on pathogens, which helps initiate immune responses. Unlike many other C-type lectins that are broadly expressed on various immune cells, CLEC4C is primarily expressed on pDCs, a unique cell type specializing in the secretion of large quantities of type I interferons (IFN-α/β) in response to viral infections. This exclusive expression gives CLEC4C a unique role in the immune system, particularly in antiviral defense and modulating immune responses in both innate and adaptive immunity.
CLEC4C is involved in immune modulation by inhibiting type I interferon production when cross-linked, adding another layer to immune regulation. It is studied extensively in the context of autoimmune diseases and chronic infections because of its involvement in pDC-mediated responses. Furthermore, its specific expression on pDCs has made CLEC4C a target for therapeutic interventions aimed at modulating pDC activity in autoimmune diseases and certain cancers.
CLEC4C is a type II transmembrane protein with a single-pass transmembrane domain and an extracellular C-type lectin-like domain (CTLD). Its structural characteristics are integral to its function as a receptor on plasmacytoid dendritic cells.
Extracellular C-type Lectin-like Domain (CTLD):
Transmembrane Domain:
Intracellular Tail:
Glycosylation Sites:
CLEC4C is classified as part of the C-type lectin domain family (CLEC4), specifically within the subset that is associated with type II transmembrane receptors. This family encompasses receptors that share a similar structural CTLD but have diverse roles in immune regulation and pathogen recognition. CLEC4C itself does not have significant subtypes; however, it interacts closely with other CLR family members on dendritic cells, which allows it to coordinate immune responses through cooperative signaling pathways.
CLEC4C plays several roles in immune function, especially in relation to its expression on plasmacytoid dendritic cells (pDCs):
Pathogen Recognition:
Regulation of Type I Interferon Production:
Role in Autoimmunity and Chronic Inflammatory Conditions:
Immune Cell Trafficking and Antigen Presentation:
Due to its exclusive expression on pDCs and its role in modulating type I interferon production, CLEC4C is clinically relevant in several contexts:
Autoimmune Diseases:
Chronic Viral Infections:
Cancer Immunotherapy:
CLEC4C, also known as CD303 or BDCA-2, is a type II transmembrane protein exclusively expressed on plasmacytoid dendritic cells (pDCs). It contains a C-type lectin-like domain (CTLD) that facilitates recognition and binding of carbohydrate structures on pathogens, playing a crucial role in pDC-mediated immune responses. Structurally, CLEC4C features an extracellular CTLD, a transmembrane domain, and an intracellular tail that interacts with adapter proteins to transduce signals.
Functionally, CLEC4C serves as a pathogen recognition receptor on pDCs, detecting viral and microbial components and facilitating immune responses. Importantly, CLEC4C modulates type I interferon production, acting as a feedback regulator to prevent excessive interferon release and potential immune-mediated tissue damage. In clinical settings, CLEC4C is relevant in autoimmune diseases, chronic infections, and potentially cancer immunotherapy. Its regulation of interferon production positions CLEC4C as a target for therapies aimed at controlling pDC activity, particularly in diseases where interferon dysregulation is implicated.
The study of CLEC4C continues to provide insights into immune modulation, pathogen recognition, and immune homeostasis, highlighting its importance in maintaining a balanced immune response and its potential as a therapeutic target in various immunological and inflammatory diseases.
C-type lectin domain family 4 member C (CLEC4C)
C-type lectin domain family 4 member C,DLEC,HECL,BDCA2,CD303,BDCA-2,CLECSF7,CLECSF11,Blood dendritic cell antigen 2,Dendritic lectin
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con CLEC4C - C-type lectin domain family 4 member C
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Esta página contiene 16 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC4C | abx386565 | Human C-Type Lectin Domain Family 4 Member C (CLEC4C) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | Q8WTT0 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CLEC4C | FNab01753 | anti- CLEC4C antibody | human | polyclonal | Rabbit | C-type lectin domain family 4, member C | IgG | Unconjugated | ELISA | 100µg | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx231753 | C-Type Lectin Domain Family 4 Member C (CLEC4C) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member C (CLEC4C) | Unconjugated | ELISA | 350 | 100 µg | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx402437 | C-Type Lectin Domain Family 4 Member C (CLEC4C) Antibody | Human | Monoclonal | Human | C-Type Lectin Domain Family 4 Member C (CLEC4C) | Unconjugated | ELISA | 287.5 | 50 µl | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx430709 | C-Type Lectin Domain Family 4 Member C (CLEC4C) Antibody | Human | Polyclonal | Goat | C-Type Lectin Domain Family 4 Member C (CLEC4C) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | CLEC4C | abx310353 | C-Type Lectin Domain Family 4 Member C (CLEC4C) Antibody (Biotin) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member C (CLEC4C) | Biotin | ELISA | 162.5 | 20 µg | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx310352 | C-Type Lectin Domain Family 4 Member C (CLEC4C) Antibody (FITC) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member C (CLEC4C) | FITC | 162.5 | 20 µg | Q8WTT0 | RUO | ||
Abbexa | CLEC4C | abx210315 | C-Type Lectin Domain Family 4, Member C (CLEC4C) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4, Member C (CLEC4C) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx310351 | C-Type Lectin Domain Family 4 Member C (CLEC4C) Antibody (HRP) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member C (CLEC4C) | HRP | ELISA | 162.5 | 20 µg | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx229328 | CD303 Antibody (PE) | Human | Monoclonal | Mouse | CD303 | IgG2a Kappa | PE | FCM | 93.75 | 20 tests | Q8WTT0 | RUO |
Abbexa | CLEC4C | abx229327 | CD303 Antibody (FITC) | Human | Monoclonal | Mouse | CD303 | IgG2a Kappa | FITC | FCM | 100 | 20 tests | Q8WTT0 | RUO |
Abbexa | CLEC4C | abx301625 | C-Type Lectin Domain Family 4 Member C (CLEC4C) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member C (CLEC4C) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx339764 | C-Type Lectin Domain Family 4, Member C (CLEC4C) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4, Member C (CLEC4C) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8WTT0 | RUO | |
Abbexa | CLEC4C | abx229329 | CD303 Antibody (APC) | Human | Monoclonal | Mouse | CD303 | IgG2a Kappa | APC | FCM | 112.5 | 20 tests | Q8WTT0 | RUO |
Abbexa | CLEC4C | abx104153 | C-Type Lectin Domain Family 4, Member C (CLEC4C) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4, Member C (CLEC4C) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC4C | abx066170 | Human C-Type Lectin Domain Family 4, Member C (CLEC4C) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q8WTT0 | RUO |
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