Human Bile Salt Export Pump (ABCB11) Protein

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Human Bile Salt Export Pump (ABCB11) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ABCB11

proveedor

Abbexa

reference

abx650390

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ABCB11 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ABCB11, also known as the bile salt export pump (BSEP), is an essential transporter located on the canalicular membrane of hepatocytes. It is responsible for exporting bile salts from the liver into bile, a critical step in the digestion and absorption of dietary fats and the excretion of waste products. ABCB11 is ATP-dependent and plays a vital role in maintaining bile flow and preventing bile salt accumulation, which can damage liver cells. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), a severe liver disorder characterized by impaired bile salt secretion and liver damage. Dysregulation or inhibition of ABCB11 is also implicated in drug-induced cholestasis and liver injury. Its essential function in bile production and liver health makes it a critical target for understanding and treating cholestatic diseases.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Bile Salt Export Pump (ABCB11)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.5 kDa Observed MW (SDS-PAGE): 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu421-Ala663 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCB11


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reference

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