Human Bile Salt Export Pump (ABCB11) ELISA Kit

Este producto es parte de ABCB - ATP binding cassette subfamily B member
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Bile Salt Export Pump (ABCB11) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx514827
tested applications
ELISA

Description

Human Bile Salt Export Pump (ABCB11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Bile Salt Export Pump (ABCB11) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
Bile Salt Export Pump (ABCB11)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
78 pg/ml - 5000 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O95342
Alias
ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP
Background
Elisa kits for ABCB11
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ABCB11, also known as the bile salt export pump (BSEP), is an essential transporter located on the canalicular membrane of hepatocytes. It is responsible for exporting bile salts from the liver into bile, a critical step in the digestion and absorption of dietary fats and the excretion of waste products. ABCB11 is ATP-dependent and plays a vital role in maintaining bile flow and preventing bile salt accumulation, which can damage liver cells. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), a severe liver disorder characterized by impaired bile salt secretion and liver damage. Dysregulation or inhibition of ABCB11 is also implicated in drug-induced cholestasis and liver injury. Its essential function in bile production and liver health makes it a critical target for understanding and treating cholestatic diseases.

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