Human Bile Salt Export Pump (ABCB11) ELISA Kit

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Human Bile Salt Export Pump (ABCB11) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for ABCB11

proveedor

Abbexa

reference

abx514827

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Bile Salt Export Pump (ABCB11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Bile Salt Export Pump (ABCB11) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

ABCB11, also known as the bile salt export pump (BSEP), is an essential transporter located on the canalicular membrane of hepatocytes. It is responsible for exporting bile salts from the liver into bile, a critical step in the digestion and absorption of dietary fats and the excretion of waste products. ABCB11 is ATP-dependent and plays a vital role in maintaining bile flow and preventing bile salt accumulation, which can damage liver cells. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), a severe liver disorder characterized by impaired bile salt secretion and liver damage. Dysregulation or inhibition of ABCB11 is also implicated in drug-induced cholestasis and liver injury. Its essential function in bile production and liver health makes it a critical target for understanding and treating cholestatic diseases.

Características del producto

category

ELISA Kits


immunogen target

Bile Salt Export Pump (ABCB11)


reactivity

Human


test range

78 pg/ml - 5000 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ABCB11


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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