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Precio
618.75€ (96 tests)
Human ATP-Dependent Translocase ABCB1 (ABCB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP-Dependent Translocase ABCB1 (ABCB1) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of P-glycoprotein 1No significant cross-reactivity or interference between P-glycoprotein 1 and analogues was observed.
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
ELISA Kits
ATP-Dependent Translocase ABCB1 (ABCB1)
Human
0.312 ng/ml - 20 ng/ml
< 0.13 ng/ml
Sandwich
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
5 × 96 tests
10 × 96 tests
ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
ABCB1
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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