Human ATP-Dependent Translocase ABCB1 (ABCB1) CLIA Kit

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Human ATP-Dependent Translocase ABCB1 (ABCB1) CLIA Kit

Pida mas información

935106861

info@markelab.com

Precio

643.5€ (96 tests)

CLIA Kits ABCB1

proveedor

Abbexa

reference

abx197424

Tested Applications

CLIA

reactivity

Human

status

RUO

clonality

Descripción

Human Permeability Glycoprotein (P-GP) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Permeability Glycoprotein (P-GP).


Background

ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.

Características del producto

category

CLIA Kits


immunogen target

ATP-Dependent Translocase ABCB1 (ABCB1)


reactivity

Human


test range

62.5 pg/ml - 4000 pg/ml


sensitivity

37.5 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Chemiluminescent


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ABCB1


dry ice

No


note

The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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