Human ATP-Dependent Translocase ABCB1 (ABCB1) CLIA Kit
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Pida mas información
935106861
info@markelab.com
Precio
643.5€ (96 tests)
CLIA Kits ABCB1
proveedor
Abbexareference
abx197424Tested Applications
CLIAreactivity
Humanstatus
RUOclonality
Descripción
Human Permeability Glycoprotein (P-GP) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Permeability Glycoprotein (P-GP).
Background
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
Características del producto
category
CLIA Kits
immunogen target
ATP-Dependent Translocase ABCB1 (ABCB1)
reactivity
Human
test range
62.5 pg/ml - 4000 pg/ml
sensitivity
37.5 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Chemiluminescent
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ABCB1
dry ice
No
uniprot id
note
The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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