Human ATP Binding Cassette Transporter D4 (ABCD4) Protein

Este producto es parte de ABCD - ATP Binding Cassette Transporter D
Product Graph
208€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Human ATP Binding Cassette Transporter D4 (ABCD4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650404
tested applications
WB, SDS-PAGE

Description

Human ABCD4 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
ATP Binding Cassette Transporter D4 (ABCD4)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 31.6 kDa  Observed MW (SDS-PAGE): 31 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Leu356-Glu606
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O14678
Alias
ABC41,EST352188,MAHCJ,P70R,P79R
Background
Protein ABCD4
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ABCD4 is a peroxisomal and lysosomal ATP-binding cassette transporter that facilitates the transport of vitamin B12 (cobalamin) across intracellular membranes, enabling its proper processing and utilization. ABCD4 works in conjunction with lysosomal proteins such as LMBD1 to release vitamin B12 from lysosomes into the cytosol, where it is converted into its active forms, methylcobalamin and adenosylcobalamin, essential for DNA synthesis and energy metabolism. Mutations in ABCD4 are associated with cobalamin deficiency type F, which leads to megaloblastic anemia, neurological symptoms, and other metabolic abnormalities. ABCD4 is expressed in various tissues, with critical roles in maintaining vitamin B12 homeostasis and supporting metabolic pathways dependent on this essential cofactor.

Related Products

abx014232

ATP Binding Cassette Transporter D4 (ABCD4) Antibody

Rabbit polyclonal antibody against ABCD4 protein. Immunogen region is Internal.

Ver Producto
abx037631

ATP Binding Cassette Transporter D4 (ABCD4) Antibody

Rabbit Polyclonal against the ABCD4 protein.

Ver Producto
abx130577

ATP Binding Cassette Transporter D4 (ABCD4) Antibody

ABCD4 Antibody is a Rabbit Polyclonal against ABCD4.

Ver Producto