Human ATP Binding Cassette Transporter C8 (ABCC8) Protein
234€ (10 µg)
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name
Human ATP Binding Cassette Transporter C8 (ABCC8) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166888
tested applications
WB, SDS-PAGE
Description
ATP Binding Cassette Transporter C8 (ABCC8) Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP Binding Cassette Transporter C8 (ABCC8) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 31.9 kDa Observed MW (SDS-PAGE): 32 kDa Concentration: Prior to lyophilization: 250 µg/ml Sequence Fragment: Val679-Thr929 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl and 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ABC36,HHF1,HI,HRINS,MRP8,PHHI,PNDM3 |
| Background | Protein ABCC8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ATP Binding Cassette Subfamily C Member 8 (ABCC8) encodes a sulfonylurea receptor that functions as a regulatory subunit of ATP-sensitive potassium (K-ATP) channels. These channels play a critical role in glucose-induced insulin secretion in pancreatic beta cells by coupling metabolic signals to membrane depolarization. ABCC8 mutations are linked to congenital hyperinsulinism, a condition characterized by unregulated insulin secretion leading to hypoglycemia. The protein is also expressed in cardiac and skeletal muscle tissues, where it regulates cellular energy homeostasis and membrane excitability under metabolic stress. Pharmacologically, ABCC8 is targeted by sulfonylureas and meglitinides, drugs used to treat type 2 diabetes by stimulating insulin secretion. Research highlights its potential role in cardiovascular physiology, particularly in ischemic preconditioning, where it helps protect tissues during periods of low oxygen supply.
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