Name: Human ATP Binding Cassette Transporter C8 (ABCC8) ELISA Kit
Brand: Abbexa
SKU: abx150510
Price: 687.5 EUR
Availability: OnlineOnly

Descripción

Human ATP Binding Cassette Transporter C8 (ABCC8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP Binding Cassette Transporter C8 (ABCC8) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of ATP Binding Cassette Transporter C8 (ABCC8)No significant cross-reactivity or interference between ATP Binding Cassette Transporter C8 (ABCC8) and analogues was observed.

Background

ATP Binding Cassette Subfamily C Member 8 (ABCC8) encodes a sulfonylurea receptor that functions as a regulatory subunit of ATP-sensitive potassium (K-ATP) channels. These channels play a critical role in glucose-induced insulin secretion in pancreatic beta cells by coupling metabolic signals to membrane depolarization. ABCC8 mutations are linked to congenital hyperinsulinism, a condition characterized by unregulated insulin secretion leading to hypoglycemia. The protein is also expressed in cardiac and skeletal muscle tissues, where it regulates cellular energy homeostasis and membrane excitability under metabolic stress. Pharmacologically, ABCC8 is targeted by sulfonylureas and meglitinides, drugs used to treat type 2 diabetes by stimulating insulin secretion. Research highlights its potential role in cardiovascular physiology, particularly in ischemic preconditioning, where it helps protect tissues during periods of low oxygen supply.

Características del producto

immunogen target

ATP Binding Cassette Transporter C8 (ABCC8)

reactivity

Human

test range

0.312 ng/ml - 20 ng/ml

sensitivity

< 0.12 ng/ml

assay type

Sandwich

assay data

Quantitative

detection method

Colorimetric

sample type

Tissue homogenates,Cell lysates,Other biological fluids

size 1

96 tests

size 2

5 × 96 tests

size 3

10 × 96 tests

alias

ABC36,HHF1,HI,HRINS,MRP8,PHHI,PNDM3

storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit

or code

ABCC8

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q09428

gene id

https://www.ncbi.nlm.nih.gov/gene/6833

note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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Tested Applications

reactivity

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status

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reference

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Tested Applications

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reactivity

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