Human ATP Binding Cassette Transporter C8 (ABCC8) CLIA Kit
845€ (96 tests)
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name
Human ATP Binding Cassette Transporter C8 (ABCC8) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx494340
tested applications
CLIA
Description
Human ATP Binding Cassette Transporter C8 (ABCC8) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | ATP Binding Cassette Transporter C8 (ABCC8) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 1.25 ng/ml - 20 ng/ml |
| Sensitivity | < 0.52 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q09428 |
| Gene ID | 6833 |
| OMIM | 240800 |
| Alias | ABC36,HHF1,HI,HRINS,MRP8,PHHI,PNDM3 |
| Background | CLIA Kits ABCC8 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ATP Binding Cassette Subfamily C Member 8 (ABCC8) encodes a sulfonylurea receptor that functions as a regulatory subunit of ATP-sensitive potassium (K-ATP) channels. These channels play a critical role in glucose-induced insulin secretion in pancreatic beta cells by coupling metabolic signals to membrane depolarization. ABCC8 mutations are linked to congenital hyperinsulinism, a condition characterized by unregulated insulin secretion leading to hypoglycemia. The protein is also expressed in cardiac and skeletal muscle tissues, where it regulates cellular energy homeostasis and membrane excitability under metabolic stress. Pharmacologically, ABCC8 is targeted by sulfonylureas and meglitinides, drugs used to treat type 2 diabetes by stimulating insulin secretion. Research highlights its potential role in cardiovascular physiology, particularly in ischemic preconditioning, where it helps protect tissues during periods of low oxygen supply.
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