Human ATP Binding Cassette TransPorter C3 (ABCC3) Protein

Este producto es parte de ABCC - ATP binding cassette subfamily C
Human ATP Binding Cassette TransPorter C3 (ABCC3) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ABCC3

proveedor

Abbexa

reference

abx167050

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ATP Binding Cassette Transporter C3 Protein is a recombinant Human protein expressed in E. coli.


Background

ABCC3, also known as multidrug resistance-associated protein 3 (MRP3), is expressed on the basolateral membrane of hepatocytes, enterocytes, and other epithelial cells. It facilitates the efflux of organic anions, including bile acids, glucuronides, and sulfated metabolites, from cells into the bloodstream for subsequent excretion via the kidneys. ABCC3 is upregulated in conditions where bile flow is impaired, such as cholestasis, serving as a compensatory mechanism to reduce intracellular bile acid toxicity. It also transports drug conjugates and metabolites, playing a critical role in drug resistance and disposition. ABCC3 is highly expressed in tissues such as the liver, intestines, and pancreas, where it contributes to detoxification and cellular protection. Dysregulation of ABCC3 has been linked to altered drug pharmacokinetics and resistance to chemotherapy.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ATP Binding Cassette Transporter C3 (ABCC3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 29.5 kDa Observed MW: 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe1291-Asp1523 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCC3


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABC31,EST90757,MLP2,Multidrug resistance-associated protein 3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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Tested Applications

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reference

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reactivity

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