Human ATP Binding Cassette TransPorter C3 (ABCC3) Protein

Background

ABCC3, also known as multidrug resistance-associated protein 3 (MRP3), is expressed on the basolateral membrane of hepatocytes, enterocytes, and other epithelial cells. It facilitates the efflux of organic anions, including bile acids, glucuronides, and sulfated metabolites, from cells into the bloodstream for subsequent excretion via the kidneys. ABCC3 is upregulated in conditions where bile flow is impaired, such as cholestasis, serving as a compensatory mechanism to reduce intracellular bile acid toxicity. It also transports drug conjugates and metabolites, playing a critical role in drug resistance and disposition. ABCC3 is highly expressed in tissues such as the liver, intestines, and pancreas, where it contributes to detoxification and cellular protection. Dysregulation of ABCC3 has been linked to altered drug pharmacokinetics and resistance to chemotherapy.