Human ATP Binding Cassette Transporter B8 (ABCB8) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ABCB8
proveedor
Abbexareference
abx650383Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ABCB8 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ABCB8 is a mitochondrial ATP-binding cassette transporter involved in the export of iron-sulfur cluster intermediates and possibly other substrates from mitochondria to the cytosol. This function is critical for maintaining cellular iron homeostasis, facilitating the proper assembly of iron-sulfur cluster-containing proteins, and regulating oxidative stress. ABCB8 is highly expressed in metabolically active tissues, such as the heart, skeletal muscle, and liver, where mitochondrial function is crucial. Dysregulation of ABCB8 can lead to mitochondrial iron overload, contributing to oxidative damage and cellular dysfunction, particularly in cardiomyocytes. Emerging evidence suggests that ABCB8 plays a protective role in maintaining mitochondrial integrity under stress conditions, making it an important factor in cardiovascular health and mitochondrial-related diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
ATP Binding Cassette Transporter B8 (ABCB8)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 32.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val472-Ser735 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCB8
dry ice
No
availability
Shipped within 5-7 working days.
alias
EST328128,M-ABC1,MABC1,MITOSUR
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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proveedor
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abx005962Tested Applications
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RUOclonality
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proveedor
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abx038131Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
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WB, IHC, IF/ICCreactivity
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