Human ATP Binding Cassette Transporter B8 (ABCB8) Protein

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Human ATP Binding Cassette Transporter B8 (ABCB8) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ABCB8

proveedor

Abbexa

reference

abx650383

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ABCB8 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ABCB8 is a mitochondrial ATP-binding cassette transporter involved in the export of iron-sulfur cluster intermediates and possibly other substrates from mitochondria to the cytosol. This function is critical for maintaining cellular iron homeostasis, facilitating the proper assembly of iron-sulfur cluster-containing proteins, and regulating oxidative stress. ABCB8 is highly expressed in metabolically active tissues, such as the heart, skeletal muscle, and liver, where mitochondrial function is crucial. Dysregulation of ABCB8 can lead to mitochondrial iron overload, contributing to oxidative damage and cellular dysfunction, particularly in cardiomyocytes. Emerging evidence suggests that ABCB8 plays a protective role in maintaining mitochondrial integrity under stress conditions, making it an important factor in cardiovascular health and mitochondrial-related diseases.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ATP Binding Cassette Transporter B8 (ABCB8)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 32.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val472-Ser735 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCB8


dry ice

No


availability

Shipped within 5-7 working days.


alias

EST328128,M-ABC1,MABC1,MITOSUR


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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