Human Glucosylceramide Transporter ABCA12 (ABCA12) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ABCA12
proveedor
Abbexareference
abx166885Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Glucosylceramide Transporter ABCA12 Protein is a recombinant Human protein expressed in E. coli.
Background
ABCA12 (ATP-binding cassette sub-family A member 12) is a member of the ATP-binding cassette (ABC) transporter superfamily, which is responsible for translocating a wide variety of molecules across cellular membranes. ABCA12 is crucial for the proper transport of lipids, particularly glucosylceramides, in the epidermis. These lipids play an essential role in forming the skin’s barrier function, protecting against environmental insults and preventing water loss. ABCA12 is highly expressed in keratinocytes within the epidermis, particularly in the granular layer, where it facilitates the secretion of lipids into lamellar bodies. These organelles are essential for maintaining the integrity of the stratum corneum, the outermost layer of the skin. Dysregulation or mutations in the ABCA12 gene can result in severe skin disorders, most notably Harlequin ichthyosis (HI), a rare but devastating congenital condition.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Glucosylceramide Transporter ABCA12 (ABCA12)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val1346-Thr1577 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCA12
dry ice
No
availability
Shipped within 5-7 working days.
alias
ARCI4A,ARCI4B,ICR2B,LI2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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