Human Glucosylceramide Transporter ABCA12 (ABCA12) Protein
234€ (10 µg)
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name
Human Glucosylceramide Transporter ABCA12 (ABCA12) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166885
tested applications
WB, SDS-PAGE
Description
Glucosylceramide Transporter ABCA12 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Glucosylceramide Transporter ABCA12 (ABCA12) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val1346-Thr1577 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86UK0 |
| Gene ID | 26154 |
| Alias | ARCI4A,ARCI4B,ICR2B,LI2 |
| Background | Protein ABCA12 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ABCA12 (ATP-binding cassette sub-family A member 12) is a member of the ATP-binding cassette (ABC) transporter superfamily, which is responsible for translocating a wide variety of molecules across cellular membranes. ABCA12 is crucial for the proper transport of lipids, particularly glucosylceramides, in the epidermis. These lipids play an essential role in forming the skin’s barrier function, protecting against environmental insults and preventing water loss. ABCA12 is highly expressed in keratinocytes within the epidermis, particularly in the granular layer, where it facilitates the secretion of lipids into lamellar bodies. These organelles are essential for maintaining the integrity of the stratum corneum, the outermost layer of the skin. Dysregulation or mutations in the ABCA12 gene can result in severe skin disorders, most notably Harlequin ichthyosis (HI), a rare but devastating congenital condition.
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