Glucosylceramide Transporter ABCA12 (ABCA12) Antibody

Background

ABCA12 (ATP-binding cassette sub-family A member 12) is a member of the ATP-binding cassette (ABC) transporter superfamily, which is responsible for translocating a wide variety of molecules across cellular membranes. ABCA12 is crucial for the proper transport of lipids, particularly glucosylceramides, in the epidermis. These lipids play an essential role in forming the skin’s barrier function, protecting against environmental insults and preventing water loss. ABCA12 is highly expressed in keratinocytes within the epidermis, particularly in the granular layer, where it facilitates the secretion of lipids into lamellar bodies. These organelles are essential for maintaining the integrity of the stratum corneum, the outermost layer of the skin. Dysregulation or mutations in the ABCA12 gene can result in severe skin disorders, most notably Harlequin ichthyosis (HI), a rare but devastating congenital condition.